The Kumar Group

Biological Materials

                                 Physical Chemistry Open Source Textbook (free downloads)

Module 1, Chapters 1 to 6 (Properties of Gases),

    iBook, click here: Mod1Ch1-6Aug29ePub.epub                           PDF: Mod1Ch1-6Aug29Pages.pdf

Module 2, Chapters 7 to 12 (First Law)

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Module 3, Chapters 13 to 15 (Second and the Third Law)

    iBook, click here: Mod3Ch13-15Sept1RFL.epub                         PDF: Mod3Ch13-15Sept1pdf.pdf.

Module 4, Chapters 16 to 18 (Spontaneity and Equilibrium)

    iBook 4, click here:Module4Ch16-18sep29ePUB.epub               PDF: Module4Ch16-18sep18pdf.pdf


Nanoparticles made from ordinary protein, serum albumin, B. S. Stromer, C. V. Kumar, Adv. Funct. Mater. 2017, 27, 1603874. Click here!

Buy the nanoparticles here:

Our Mission

Our mission is to apply basic principles of chemistry to solve important problems in biology. Our major goal is to make Protein-based Materials for functional devices.

BionanoMaterials - Our hypothesis is that enzymes can be stabilized by placing them reduced dimensional space.  That is, enzymes in one dimensional space will be more stable than in two dimensional space, and they will be more stable in two dimensional space than in three dimensional space.

To test this hypothesis, we encapsulate enzymes in the two-dimensional space of inorganic layered materials and testing their stability.  Our encapsulated enzymes catalyze reactions near the boiling point of water. This is very unusual, but exciting.

Protein-Polymer Conjugates - in collaboration with the Kasi group, we are designing polymers to wrap individual enzyme molecules.  These conjugates enhance the stability of the enzymes well beyond boiling point of water, at normal pressure.  These are providing exciting new applications in biocatalysis, biosensing and biofuel cells.

Light Harvesting Complexes - We are making artificial complexes of proteins and chemically modifying proteins with small organic molecules.  These protein/dye complexes are showing amazing ability for solar light harvesting.

Biophilic Graphene Oxide - We are developing novel protein-glues that can pacify the hydrophobic regions of graphene oxide and convert it into a biophilic material for the adsorption of biomolecules.  The biophilic graphene oxide is becoming an exciting nanomaterial for applications in biofuel cell applications and biocatalysis.

Our Motto: One lamp can light a thousand!

Publication list:

Refereed Publications of Professor Challa Vijaya Kumar (180 published, 1 submitted, >8700 Citations, h-index of 39 and I10-index of 113, Google Scholar) (undergraduate authors in bold)

Appeared or Accepted (Refereed Papers, Undergraduate Authors in Bold)

180. Pattammattel, A., Stromer, B. S., Baveghems, C. and Kumar, C. V., Stimuli-responsive protein hydrogels for potential applications in enzymology and drug delivery, J. Chem. Sci., in press, 2018.

179. Buranaprapuk, A., Kumar, C. V., Jedi's light sabre: Site specific photocleavage of proteins with light, Srinakarinvirot Sci. J., in press, 2018.

178. Stromer, B. S., Roy, S., Limbacher, M., Narzary, B., Bordoloi, M., Waldman, J., and C. V. Kumar, Bioconj. Chem., 2018 (in press).

177. Puglia, M. K., Anuganti, M., Lin, Y., and Kumar, C. V., Facile, protein-assisted synthesis of biographene for enzymology studies, Method. Enzmol., in Press, 2018.

176. O’Neill, M., Puglia, M. K., and Kumar, C. V., advanced development of space photovoltain concentrators using robust lenses, multi-junction cells, and graphene radiators, Proceedings of WCPEC-7, 2018.

175. Riccardi, C. M., A Modular Approach for Interlocking Enzymes in Whatman Paper, Angew. Chem. Int. Ed. (Engl), 2018, appeared.

174. Limbacher, M. R., Puglia, M. K., Riccardi, C. M. and Kumar, C. V., Interlocking enzymes in graphene coated cellulose paper for increased enzymatic efficiency, Method. Enzymol., in press, 2018.

173. Shen, M., Amit A. Joshi, A. A., Vannam, R., Dixit, C. K., Hamilton, R. G., Kumar, C. V., Mark W. Peczuh, M. W., and Rusling, J. F., Epitope-Resolved Detection of Peanut-Specific IgE Antibodies by Surface Plasmon Resonance Imaging, ChemBioChem, 2017, 10.1002/cbic.201700513.

172. Baveghems, C.; Anuganti, M.; Pattammattel, A.; Lin, Y.; Kumar, C. V., Tuning Enzyme/α-Zr(IV)Phosphate Nanoplate Interactions via Chemical Modification of Glucose Oxidase", 2017, Langmuir, DOI:10.1021/acs.langmuir.7b02919.

171. Ghimire, A.; Pattammattel, A.; Maher, C.; Kasi, R. M.; Kumar, C. V., 3-Dimensional, Enzyme Biohydrogel Electrode for Improved Bioelectrocatalysis, 2017, Adv. Mater. and Interfaces, DOI:10.1021/acsami.7b13606.

170. Pattammattel, A., Pande, P., Kuttappan, D., Basu, A. K., Amalaradjou, M. A., and Kumar, C. V., Controlling Grapehne-Bio Interface: Dispersions in sera with enhanced stability and reduced toxicity, Langmuir, 2017, 10.1021/acs.langmuir.7b02854.

169. Benson, K. R., Pattammattel, A., Ghimire, A., and Kumar, C. V., Protein BioPhosphors: Biodegradable, multi-functional, protein-based, hydrogels for white emission, sensing and pH detection, Adv. Funct. Mater., 2017, 27, 1702955; 10.1002/adfm.201702955.

168. Zore, O. V., Pande, P., Okifo, O., Basu, A. K., Kasi, R. M., Kumar, C. V., NanoArmoring: Strategies for the Preparation of Multi-Catalytic Enzyme Polymer Conjugates and Enhancement of High Temperature Biocatalysis, RSC Advances, 2017, 7, 29563-74.

167. Zore, O. V. Kasi, R. M., Kumar, C.V., Armored Enzyme–Nanohybrids and Their Catalytic Function Under Challenging Conditions, Methods in Enzymology, 2017, 590, 169-192.

166. Riccardi, C. M., Kasi, R. M., Kumar, C. V., Nanoarmoring of Enzymes by Interlocking in Cellulose Fibers, With Poly (Acrylic Acid), Methods in Enzymology 2017, 590, 475-500.

165. Stromer, B., Limbacher, M. L., Jayaram, D. T., Yenjai, S., Chowdhury, R., Ramiah, D., and Kumar, C. V., Chiral photochemical scissors: Toward site specific cleavage of proteins with light, Journal of Photochemistry and Photobiology A: Chemistry, 2017, 340, 181-200.

164. Mosa, I.M., Pattammattel, Kadimisetty, K., Pande, P., ElKady,M. F., Bishop, G. W., Novac, M. J., Kaner, R. B., Basu, A. K., Kumar, C. V., Rusling, J. F., Ultrathin Graphene–Protein Supercapacitors for Miniaturized Bioelectronics, Adv. Ener. Mater., 2017, DOI: 10.1002/aenm.201700358.

163. Biological Materials CV Kumar, book chapter in ‘Inorganic Nanosheets and Nanosheet-Based Materials’, 523-542, 2017.

162. CV Kumar, A Pattammattel, BioGraphene: Direct Exfoliation of Graphite in a Kitchen Blender for Enzymology Applications, Methods in Enzymology, 2016, 571, 225-244.

161. IK Deshapriya, CV Kumar, Rationally Designed “Stable-on-the-Table” NanoBiocatalysts Bound to Zr (IV) Phosphate Nanosheets, Method. Enzymol., 2016, 571, 151-175.

160. CL Baveghems, A Pattammattel, CV Kumar, Designer Histone Complexes: Controlling Protein–DNA Interactions with Protein, Charge as an “All-or-None” Digital Switch, J. Phys. Chem., B 2016, 120, 11880-11887, 2016.

159. RK Kamat, Y Zhang, M Anuganti, W Ma, I Noshadi, H Fu, S Ekatan, Enzymatic Activities of Polycatalytic 2

Complexes with Nonprocessive Cellulases Immobilized on the Surface of Magnetic Nanoparticles, Langmuir, 2016, 32, 11573-79.

158. CV Kumar, BS Stromer, Protein fluorescent nanoparticles and methods of synthesis there of, US Patent App. 15/216,420, 2016.

157. Stromer, B.S, Kumar, C.V, WhiteEmitting Protein Nanoparticles for CellEntry and pH Sensing, Adv. Funct. Mater., 2016, 27, 1603874.

156. CV Kumar, Rational Design of Enzyme-Nanomaterials, PREFACE, Methods in Enzymology, 2016.

155. CM Riccardi, D Mistri, O Hart, M Anuganti, Y Lin, RM Kasi, CV Kumar, Covalent interlocking of glucose oxidase and peroxidase in the voids of paper: enzyme–polymer “spider webs”, Chem. Commun., 2016, 52, 2593-2596.

154. Novak, M. J., Pattammattel, A., Koshmerl, B., Puglia, M., Williams, C., and Kumar, C. V., ‘Stable-on-the-Table’ Enzymes: Engineering Enzyme-Graphene Oxide Interface for unprecedented stability of the biocatalysts, ACS Catalysis, 2015, 6, 339-447.

153. Pattammattel, A., and Kumar, C. V., Kitchen chemistry 101: Efficient exfoliation of high quality graphene with a blender and edible proteins, Adv. Funct. Mater., 2015, 25, 7088-98.

152. Ghimire, A., Zore, O., V. K. Thilakarathne, V. A. Briand, P. J. Lenehan, Lei, Y., R. M. Kasi, C. V. Kumar, Ultra-Stable, Hemoglobin-Poly(Acrylic) Acid “Nanogels”, Sensors, 2015,

151. Kumar, C. V., Benson, K. B., Baveghems, C., Stromer, B. S., Thilakarathne, V. K., Novac, M. J., and Rossi, Toward the design of bio-solar cells: High efficiency cascade energy transfer among four donor-acceptor dyes self assembled in highly ordered protein-DNA matrix, RSC Advances, 2015, 5, 72416-72422, DOI:10.1039/C5RA14208C.

150. O. Zore, A. Pattamattel, S. Gnanaguru, C. V. Kumar and R. Kasi, ‘Bienzyme-Polymer-Graphene Oxide quaternary hybrid biocatalysts: Efficient substrate channeling at chemically and thermally denaturing conditions, ACS Catalysis, 2015,5, 4979-4988,

149. A. Pattammattel, C. L. Williams, P. Pande, W. G. Tsui, A. K. Basu and C. V. Kumar, Biological relevance of oxidative debris present in as-prepared graphene oxide, RSC Advances, 2015, 5, 59364-59372, DOI: 10.1039/C5RA10306A.

148. Deshapriya, I., Stromer, B., S., Kim, C. S., Patel, V., Gutkind, J. S., and Kumar, C. V., Novel, protein-based nanoparticles: Improved half-lives, retention of protein structure and activities, Bioconj. Chem., 2015, 26, 396-404, DOI: 10.1021/bc500621h.

147. A. A. Joshi, M. W. Peczuh, C. V. Kumar, and J. F. Rusling, Ultrasensitive Carbohydrate-Peptide SPR imaging microarray for Diagnosing IgE mediated peanut Allergy, Analyst, (2014), 139, 5728-33, DOI:10.1039/c4an01544d.

146. Sun, X., Ma, X., Kumar, C. V., and Lei, Y., Protein-based sensitive, selective and rapid fluorescence detection of picric acid, Anal. Methods, 2014, 6. 8464-68, DOI: 10.1039/C4AY01941E.

145. C. M. Riccardi, K. S. Cole, K. R. Benson, J. Ward, K. Bassett, Y. Zhang, O. Zore, B. Stromer, R. M. Kasi, C. V. Kumar, Toward ‘Stable-on-the-Table’ Enzymes: Improving key properties of catalase by simple covalent conjugation with poly(acrylic acid), Bioconj. Chem., (2014) 25, 1501-1510.

144. I. K. Deshapriya, C. S. Kim, M. J. Novak, C. V. Kumar, Biofunctionalization of alpha-Zr(IV)Phosphate Nanosheets: Towards Rational Control of enzyme affinities, activities and structure retention, Appl. Materials and Interfaces, (2014) 6, 9643-9653.

143. Ghimire, A., Kasi, R. M. Kumar, C. V., Lysozyme/poly(acrylic) acid interactions: pH as a measure to control the binding thermodynamics, J. Phys. Chem., (2014) 118, 5026-33.

142. Zore, O. V., Lenehan, P. J., Kumar, C. V., Kasi, R. M., Efficient biocatalysis in organic media with hemoglobin and poly(acrylic acid) nanogels, Langmuir, (2014) 30, 5176-84.

141. Ramasamy, E., Deshapriya, I. K., Kulasekharan, R., Kumar, C. V., and Ramamurthy, V., Photophysical studies of an encapsulated neutral guest intercalated into the 2-dimensional space of α-Zr(IV) phosphate, Photochem. Photobio. Sci., (2014) 13, 301-309.

140. Pattammattel, A., Puglia, M., Chakraborty, S., Deshapriya, I. K., Dutta, P. K., and Kumar, C. V., Tuning the activities and structures of enzymes bound to grapheme oxide by one step biophilization, Langmuir, (2013) 29, 15643-15654.

139. Deshapriya, I. K., and Kumar, C. V., Nano-Bio Interfaces: Charge control of enzyme/inorganic interfaces for advanced biocatalysis, Langmuir, (2013) 29, 14001-14016.

138. Kamat, R., Lin, Y., and Kumar, C. V., Magnetic nanoparticles with multivalent interactions to enhance activities of cellulase catalytic domains, Applied Materials and Interfaces, (2013) 5, 8486-8494. 3

137. Pattammattel, A., Deashapriya, I., Chowdhury, R., and Kumar, C. V., Metal-enzyme frameworks: Role of metal ions in promoting enzyme self-assembly on a-zirconium (IV) phosphate, Langmuir 2013, 29, 2971-81.

136. Mani, V., Wasalathanthri, D. P., Joshi, A. A., Kumar, C. V., and Rusling, J. F., Highly efficient binding of paramagnetic beads bioconjugated with 100,000 or more antibodies to protein coated surfaces, Anal. Chem., (2012) 84, 10485-91.

135. Tuning Hemoglobin-Poly(Acrylic Acid) Interactions by Controlled Chemical Modification with Triethylene tetramine, Thilakarathne, V. K., Briand, V. A., Kasi, R. M., Kumar, C. V., J. Phys. Chem., (2012) 116, 12783.

134. Ultra-stable hemoglobin-poly(acrylic) acid conjugates, Mudhivarthy, V. K., Cole, K. S., Novak, M. J., Kipphut, W. Deshapriya, I. K., Zhou, Y., Kasi, R. M., and Kumar, C. V., J. Mater. Chem, (2012) 22, 20423-20433.

133. Chowdhury, R., Stromer, B. S., Pokharel, B., and Kumar, C. V., Control of enzyme-solid interactions by chemical modification, Langmuir (2012) 28, 11881-9.

132. Briand, V. A., Thilakarathne, V. K., Kasi, R. M., and Kumar, C. V., Novel surface plasmon resonance sensor for the detection of heme at biological levels via highly selective recognition by apo-hemoglobin, Talanta, (2012), 99, 113-8.

131. Deshapriya, I. Kumar, C. V., Novel Synthesis of Nanoparticles, invited book chapter, in “Applications of Nanomaterials”, Studium Press, (2012) Houston Texas USA, Vol. Chapter 3, 53-86.

130. Kumar, C. V., DNA-based Bionanocatalysts, invited book chapter, in “Applications of Nanomaterials”, (2012) Studium Press, Houston Texas USA, Vol 10, Chapter 7, pp 147-189.

129. Briand, V. A.; Thilakarathne, V.; Kumar, C. V.; Kasi, R. M., Protein-polymer conjugates for use as hybrid functional materials, PMSE Preprints (2011).

128. Thilakarathne, V.; Briand, V. A.; Zhou, Y.; Kasi, R. M.; Kumar, C. V. Protein-polymer conjugates: Improving the stability of hemoglobin with poly(acrylic acid), Langmuir (2011), 27, 7663-7671.

127. Malaikaew, P.; Svasti, J.; Kumar, C. V.; Buranaprapuk, A., Photocleavage of avidin by a pyrenyl probe, J. Photochem. and Photobiol., B: Biology (2011), 103, 251-255.

126. Krishnan, S.; Mani, V.; Wasalathanthri, D.; Kumar, C. V.; Rusling, J. F. Attomolar detection of a cancer biomarker protein in serum by surface plasmon resonance using superparamagnetic particle labels, Angew. Chem. Inter. Ed., (2011), 50, 1175-1178.

125. Briand, V. A., Kumar, C. V. and Kasi, R. M., Protein-Polymer Conjugates, in “Encyclopedia of Polymer Science and Technology”, Wiley: New York 2011.

124. Duff, M. R., Jr.; Fyvie, W. S.; Markad, S. D.; Frankel, A. E.; Kumar, C. V.; Gascon, J. A.; Peczuh, M. W. Computational and experimental investigations of mono-septanose binding by concanavaline A: correlation of ligand stereochemistry to enthalpies of binding, Org. & Biomol. Chem., (2011), 9, 154-164.

123. Kumar, C. V.; Deshapriya, I. K.; Duff, M. R., Jr.; Blakeley, B.; Lee-Haye, D., Novel, simple, versatile and general synthesis of nanoparticles made from proteins, nucleic acids and other materials, J. Nano Res., (2010), 12, 77-88.

122. Rusling, J. F.; Kumar, C. V.; Gutkind, J. S.; Patel, V., Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer, Analyst (Cambridge, United Kingdom) (2010), 135, 2496-2511.

120. C. V. Kumar and M. R. Duff, DNA-Based Light Harvesting Complexes, J. Am. Chem. Soc, (2009) 131, pp 15966–15967.

119. J. Thota, S. Jockusch, N. J. Turro, and C. V. Kumar, Time-resolved studies of photocleavage of proteins by Co(III) complexes, Langmuir, (2009), DOI: 10.1021/la902611j.

118. M. Duff, and C. V. Kumar, Molecular Signatures of protein binding to alpha-ZrP: Isothermal Titration Calorimetric Studies, J. Phys. Chem., (2009), 113,15083–15089.

117. M. Duff, and C. V. Kumar, Metallomics Approach: Protein cleavage via Fenton Chemistry, Metallomics, (2009) 1, 518 - 523.

116. Duff, M. R., and C. V. Kumar, Protein-Solid Interactions: Role of solvent, buffer, and temperature in protein binding to alpha-ZrP, Langmuir, (2009) 25, 12635-12643.

115. M. Duff, V. K. Mudhivarthi, C. V. Kumar, Rational design of anthracene-based DNA binders, J. Phys. Chem., B 113, 1710-1721 (2009).

114. M. Duff, C. V. Kumar, Toward building artificial light harvesting complexes: Enhanced singlet-singlet energy transfer between donor and acceptor pairs bound to albumin, J. Photochem. Photobio. Sci., 7, 1522-30 (2008).

113. J. Thota, K. Bandara, and C. V. Kumar, Photochemical Protein Scissors: Co(III) complexes, J. Photochem. Photobio. Sci., 7, 1530-39 (2008).

112. P. M. Guto, C. V. Kumar, and J. F. Rusling, Thermostable Biocatalytic Films of Enzymes and Polylysine on Electrodes and Nanoparticles in Microemulsions, Langmuir, 24, 10365-10370, (2008). 4

111. S. C. Bates, C. V. Kumar, and S. Yavuzkurt, M. Duff and V. K. Mudhivarthi, A system for capturing CO2 from a combustion exhaust Feasibility research, Technical Proceedings of the CTSI Conference and Trade Show, Boston, MA, United States, 2008 (2008) 608-611.

110. A. Buranaprapuk, Y. Malaikeaw, J. Svasti, and C. V. Kumar. Chiral Recognition, and Protein Photocleavage by A Pyrenyl Probe, J. Phys. Chem. B, 112, 9258-9265 (2008).

109. A. Bhambhani, S. Chah, E. G. Hvastkovs, G. C. Jensen, J. F. Rusling, R. N. Zare, and C. V. Kumar, Folding Control of Yeast Iso-1-cytochrome c Sandwiched Between Au and Layered Zr(IV) Phosphate Materials Monitored by Surface Plasmon Resonance, J. Phys. Chem. B., 112, 9201-9208 (2008).

108. C. V. Kumar, V. K. Mudhivarthi, and A. Bhambhani, Enzyme/DNA/apha-ZrP Nanocomposites: DNA assisted enhancement of enzymatic activity, Chemistry Today 26, 47-49 (2008).

107. C. V. Kumar and A. Bhambhani, Urea induced conformational improvement of proteins bound to solids, Micropor. Mesopor. Mater., 110, 517-527 (2008).

106. A. Bhambhani, and C. V. Kumar, Enzyme-Inorganic Nanoporous Materials: Differential Scanning Calorimetric Studies and Protein Stability, Micropor. Mesopor. Mater., 110, 223-232 (2008).

105. P. M. Guto, C. V. Kumar, and J. Rusling, Thermophilic Poly(lysine)-Enzyme Films. Biocatalysis at 90˚C, J. Phys. Chem., B, 111, 9125 (2007).

104. V. K. Mudhivarthi, A. Bhambhani, and C. V. Kumar, Novel Enzyme/DNA/Inorganic Nanomaterials: A New Generation of Biocatalysts, Dalton Trans., 5483 (2007).

103. A. Bhambhani, and C. V. Kumar, Novel Enzyme/DNA/Inorganic Materials: A New Generation of Biomaterials, in ‘Advanced Materials Research Trends’, Ed. L. Basbanes, Nova Publishers: New York, 1083 (2007).

102. M. Duff, W. B. Tan, and J. Thota, and A. Bhambhani, A. Rodger, and C. V. Kumar, Free energies of hydrogen bonding interactions with the DNA helix: Chemical control of ligand-DNA affinities and their DNA binding modes, J. Phys. Chem.,B 110, 20693 (2006).

101. A. Bhambhani, and C. V. Kumar, Tuning the Properties of Hb Intercalated in the Galleries of a-ZrP: Effect of Ionic Strength on the Structure and Activity, Chem. Mater., 18, 740 (2006).

100. A. Bhambhani and C. V. Kumar, Protein-DNA-Inorganic Materials: DNA Binding to a-ZrP Enhances Bound Protein Structure and Activity, Adv. Mater., 18, 939-42 (2006).

99. M. Duff, W. B. Tan, A. Rodger, A. Bhambhani, C. V. Kumar, Spectroscopic identification of DNA binding modes of anthracenes and DNA sequence recognition, Photochem. and Photobiol., A:Chemistry, 82, 22-30 (2006).

98. V. Jagannadham, A. Bhambhani, C. V. Kumar, The Role of Surface Functions on Thermal Stability of hemoglobin intercalated at the galleries of Zirconium Phosphate, Micropor. Mesopor. Mater, 88, 275-282 (2006).

97. M. Duff, and C. V. Kumar, Site Specific Photocleavage of Serum Albumin by Uranyl, Angew. Chem. Int. Ed. Engl., 45, 137-139 (2006).

96. A. Chaudhari and C. V. Kumar, Intercalation of Proteins at the Galleries of a-Zirconium Phosphonates: Tuning the Binding Affinities with Phosphonate Functions, Micropor. Mesopor. Mater., 77, 175 (2005).

95. S. Castro, M. Duff, N. L. Snyder, M. Morton, C. V. Kumar, M. W. Peczuh, Recognition of Ring Expanded Carbohydrates by ConA: The Effect of Anomeric Configuration on Binding Org. Biomol. Chem., 3, 3869 (2005).

94. W. B. Tan, W. Cheng, and A. Webber, A. Bhambhani, M. Duff, G. L. McLendon and C. V. Kumar, Endonuclease-like Activities of Heme Proteins, J. Biol. Inorg. Chem., 10, 790-799 (2005).

93. N. K. Modukuru, K. J. Snow, B. S. Perrin Jr., A. Bhambhani, M. Duff, and C. V. Kumar, Tuning The DNA Binding Modes of An Anthracene Derivative with Salt, J. Photochem. Photobiol. 177, 43-54 (2005).

92. N. K. Modukuru, K. J. Snow, B. S. Perrin Jr., J. Thota, and C. V. Kumar, The Contributions of a Long Side Chain to the Binding Affinity of an Anthracene Derivative to DNA, J. Phys. Chem., B 109, 11810-11818 (2005).

91. A. Buranaprapuk, and C. V. Kumar, Chiral Protein Scissors: Improved photocleavage Efficiency, Lett. In Org. Chem, 2, 554 (2005).

90. C. V. Kumar, and J. Thota Inorganic Protein Scissors: Photocleavage of lysozyme by Co(III) complexes, Inorg. Chem., 44, 825 (2005).

89. A. Chaudhari, J. Thota and C. V. Kumar, Binding and Cleavage Studies of two Proteins intercalated at the Galleries of a-Zirconium Phosphate, Micropor. Mesopor. Mater., 75, 281 (2004).

88. S. Chah, C. V. Kumar, M. R. Hammond, and R. N. Zare, Denaturation and renaturation of Self-assembled Yeast iso-1-cytochrome c on Au: Anal. Chem., 76, 2112 (2004).

87. C. V. Kumar, A. Bhambhani, and N. Hnatiuk, Zr(IV)Phosphates/Phosphonates, Handbook of Layered Materials, Eds. K. Carrado, P. Dutta, and S. Auerbach, Marcel Dekker: New York (2004).

86. C. V. Kumar, J. Thota, and A. Buranaprapuk, Protein Scissors: Photocleavage of Proteins at Specific Locations, Proc. Natl. Acad. Sci. (Indian), 114, 579 (2003). 5

85. C. V. Kumar and Chaudhari, A., Unusual thermal stabilities of some proteins intercalated in a-Zr(IV)phosphate/Phosphonates. Micropor. Mesopor. Mater., 57, 181 (2003).

84. V. Panchagnula, C. V. Kumar, and J. F. Rusling, Ultrathin layered myoglobin-polyion films functional and stable at acidic pH values, J. Am. Chem. Soc., 124, 12515, (2002).

83. C. V. Kumar, A. Chaudhari, High temperature activity of heme proteins at zirconium phosphate. Chem. Comm., 2382 (2002).

82. C. V. Kumar, A Buranaprapuk, H. C. Sze, Chiral Discrimination and Protein Photocleavage by a Pyrenyl Probe, Proc. Natl. Acad. Sci (USA)., 99, 5810-5815 (2002).

81. C. V. Kumar, and B. Raju, Supramolecular assembly of ions, molecules and proteins in the galleries of alpha-zirconium(IV)phosphate/phosphonate, Adv. in Mol. and Supramol. Photochem., Vol. 8, 505 (2001).

80. Kumar C. V. and Chaudhari, A., Reversible thermal denaturation of immobilized glucose oxidase at Zirconium Phosphate, Micropor. Mesopor. Mater., 47, 407 (2001).

79. Kumar, C. V. and A. Chaudhari, Efficient Renaturation of Immobilized Met-hemoglobin at the Galleries of alpha-Zirconium Phosphonate, Chem. Mater. 13, 238-240 (2001).

78. Kumar, C. V., A. Buranaprapuk, et al., Large chiral discrimination of a molecular probe by bovine serum albumin, Chem. Comm., 297-298 (2001).

77. Margitfalvi, J. L., E. Talas, et al, The role of cinchona alkaloids in enantioselective hydrogenation reactions: are they modifiers or hosts involved in supramolecular heterogeneous catalysis? Appl. Catal., A 191, 177-191 (2000).

76. Kumar, C. V. and A. Chaudhari, Probing the donor and acceptor dye assemblies at the galleries of a-zirconium phosphate, Micropor. Mesopor. Mater., 41, 307-318 (2000).

75. A. Buranaprapuk, and C. V. Kumar, Photochemical protein cleavage: Role of aromatic amino acid residues on the binding affinity and photocleavage efficiency by pyrenyl peptides, Tetrahedron, 56, 7019 (2000).

74. C. V. Kumar, E. H. Asuncion, and W. B. Tan, Adenine-Thymine Base Pair recognition by an Anthryl Probe from the DNA Minor Groove, Tetrahedron, 56, 7027 (2000).

73. C. V. Kumar, and A. Chaudhari, Protein Immobilized at the galleries of alpha-Zirconium phosphates: Structure and Activity Studies, J. Am. Chem. Soc., 122, 830-837 (2000).

72. C. V. Kumar, A. Buranaprapuk, and A. Chow, Artificial Metallopeptidases: Regioselective cleavage of lysozyme Chem. Comm., 597 (2000).

71. C. V. Kumar, and E. H. Asuncion, Sequence Dependent Energy transfer from DNA to an Anthryl Probe: Discrimination between GC and IC Sequences, Chem. Comm., 1219 (1999).

70. C. V. Kumar, A. Buranaprapuk, Tuning the selectivity of Protein Photocleavage: Spectroscopic and Photochemical Studies, J. Am. Chem. Soc., 121, 4202-4210 (1999).

69. C. V. Kumar, and A. Chaudhari, Photon antennas:Self Assembly of metal ions and efficient energy transfer, Micropor. and Mesopor. Mater., 32, 75-79 (1999).

68. C. V. Kumar and L. M. Tolosa, Exploring Hydrophobic Binding Sites of Calmodulin with Fluorescent Probes: Dynamic Formation of the Excimer, Ind. J. Chem., 38B, 1170-1183 (1999).

67. C. V. Kumar, A. Buranaprapuk, G. J. Opiteck, M. B. Moyer, S. Jockusch, and N. J. Turro, Photochemical Protease: Sitespecific photocleavage of hen egg lysozyme and bovine serum albumin, Proc. Natl. Acad. Sci., 95, 10361 (1998).

66. A. Buranaprapuk, S. Leach, C. V. Kumar, and J. Bocarsly, Biochim. Biophys. Acta, Protein Structure, 1387, 309 (1998).

65. C. V. Kumar, Z. J. Williams, and R. S. Turner, Suprmolecular Assemblies of Metal complexes: Light-Induced electron transfer in the galleries of a-zirconium phosphate, J. Phys. Chem. A 102, 5562 (1998).

64. C. V. Kumar and A. Buranaprapuk, Site specific photocleavage of proteins, Angew. Chem. Int. Ed. Engl., 36, 2085 (1997).

63. C. V. Kumar, W. B. Tan, and P. W. Betts, Photocleavage of DNA with visible light, J. Inorg. Biochem., 68, 177 (1997).

62. C. V. Kumar and G. L. McLendon, Nanoencapsulation of Cytochrome c and Horseradish Peroxidase at the Galleries of a-Zirconium Phosphate, Chem. Mater., 9, 863 (1997).

61. C. V. Kumar, Z. J. Williams and F. Kher, Supramolecular assemblies of organic chromophores at the a-zirconium phosphates, Micropor. Mater., 7, 161-171 (1996).

60. S. J. Advant, E. Braswell, C. V. Kumar, and D. S. Kalonia, The effect of pH and temperature on the self-association of recombinant human interleukin-2 as studied by equilibrium sedimentation, J. Pharm. Res., 12, 637-41 (1995). 6

59. A. Awaluddin, R. N. DeGuzman, C. V. Kumar, S. L. Suib, S. L. Burkett and M. E. Davis, Quenching of Tris (2,2' bipyridine) Ru(II) Luminescence by Co(III) Polypyridyl Complexes in Different Sites in and on Clays, J. Phys. Chem., 99, 9886-92 (1995).

58. C. V. Kumar and Z. J. Williams, Supramolecular Assemblies of tris(bipyridine)Ru(II) at hydrophobically Modified Zirconium Phosphate Surfaces, J. Phys. Chem., 99, 17632-9 (1995).

57. C. V. Kumar and Z. J. Williams, Supramolecular Assemblies of Chromophores at the Interlayer Regions of a-Zirconium Phosphate, Spectrum, June, (1995).

59. A. Awaluddin, R. N. DeGuzman, C. V. Kumar, S. L. Suib, S. L. Burkett and M. E. Davis, Quenching of Tris (2,2'-bipyridine) Ru(II) Luminescence by Co(III) Polypyridyl Complexes in Different Sites in and on Clays, J. Phys. Chem., 99, 9886-92 (1995).

58. C. V. Kumar and Z. J. Williams, Supramolecular Assemblies of tris(bipyridine)Ru(II) at hydrophobically Modified Zirconium Phosphate Surfaces, J. Phys. Chem., 99, 17632-9 (1995).

57. C. V. Kumar and Z. J. Williams, Supramolecular Assemblies of Chromophores at the Interlayer Regions of alpha Zirconium Phosphate, Spectrum, June, (1995).

56. C. V. Kumar and G. Rosenthal, Efficient Singlet-Singlet Energy Transfer Between Chromophores Bound to Layered Phosphates, J. Am. Chem. Soc., 116, 403 (1994).

55. C. V. Kumar and L. M. Tolosa, New Fluorescent Probe with a High Sensitivity to Hydrogen Bonding Solvents for the Development of Selective Sensors, J. Photochem. Photobiol., 78, 63-69 (1994).

54. C. V. Kumar and L. M. Tolosa, New Charge Transfer Probe for Solvent Polarity: Fluorescent Hydrogen Bonding Switch, Chem. Comm., 742-744 (1993).

53. C. V. Kumar, E. H. Asuncion and G. Rosenthal, Formation of static anthracene excimers at hydrophobic phosphate surfaces, Micropor. Mater., 1, 123-129 (1993).

52. C. V. Kumar, R. S. Turner and E. H. Asuncion, Groove Binding of a Styrylcyanine Dye to the DNA Double Helix: The Salt Effect, J. Photochem. Photobiol., 74, 231-238 (1993).

51. C. V. Kumar, E. H. Asuncion and G. Rosenthal, Formation of Static Pyrene Excimers at Hydrophobic Zirconium Phosphate Surfaces: The Salt Effect, Micropor. Mater., 1, 299-308 (1993).

50. C. V. Kumar and L. M. Tolosa, The Effect of Side Chain and Ligand Hydrophobicity on the Binding Affinity of Small Molecules to BSA, J. Phys. Chem., 97, 13914-19 (1993).

49. C. V. Kumar and E. H. Asuncion, DNA-Binding Studies and Site Selective Fluorescence Sensitization of an Anthryl Probe, J. Am. Chem. Soc., 115, 8547-7553 (1993).

48. C. V. Kumar and E. H. Asuncion, Sequence Dependent Energy Transfer from DNA to a Simple Aromatic Chromophore, Chem. Comm., 470-472 (1992).

47. S. Jain, C. V. Kumar and D. S. Kalonia, Protein-Peptide Interactions as Probed by Tryptophan Fluorescence: Serum Albumin and Enkephalin Metabolites, J. Pharm. Res., 9, 990-992 (1992).

46. C. V. Kumar, Photobiological Processes in Organized Media, in "Photoprocesses in Organized Media", ed. V. Ramamurthy, VCH Publishers, New York, July 1991, pp 783-816.

45. V. Ramamurthy, D. R. Corbin, C. V. Kumar and N. J. Turro, Modification of Photochemical Reactivity by Zeolites: Cation Controlled Photodimerization of Acenaphthalene within Faujasites, Tet. Lett., 31, 47-50 (1989).

44. Luminescence of Ruthenium(II) Polypyridyls: Evidence for Intercalative Binding to Z-DNA, A. E. Freedman, C. V. Kumar, N. J. Turro and J. K. Barton, Nucleic Acids Res., 19, 2595-2602 (1991).

43. Emission Properties of d2 Transdioxo Complexes in Aqueous Solutions of Anionic and Non-ionic Surfactants: A Sensitive Probe for Hydrophobic Binding Regions, H. H. Thorpe, C. V. Kumar, N. J. Turro and H. B. Gray, J. Am. Chem. Soc., 111, 4364-4368 (1989).

42. Mixed Ligand Complexes of Ru(II): Factors Governing Binding to DNA, A. M. Pyle, R. Meshoyerer, C. V. Kumar, N. J. Turro and J. K. Barton, J. Am. Chem. Soc., 111, 3051-58 (1989).

41. Excited State Resonance Raman Spectroscopy to Probe Alumina-SDS Hemimicelles, P. Somasundaran, J. T. Kunjappu, C. V. Kumar, N. J. Turro and J. K. Barton, Langmuir, 5, 215-218 (1989).

40. Accelerated Electron Transfer Between Metal Complexes Mediated by DNA, M. Puruggannan, C. V. Kumar, N. J. Turro and J. K. Barton, Science Washington D.C., 241, 1645-1649 (1988).

39. Are Triplet Exciplexes Involved in (2+2) Photocycloaddition of Enones to Alkenes? D. I. Schuster, G.E. Heibel, P. Brown, N.J. Turro and C.V. Kumar, J. Am. Chem. Soc., 110, 8261-63 (1988).

38. Binding of Metal Complexes to Polyelectrolytes. Model Systems for Metal Binding to Biopolymers, G. L. Duveneck, C. V. Kumar, J. K. Barton and N. J. Turro., J. Phys. Chem., 92, 8020-32 (1988).

37. Energy Redistribution and Localization in the Excited States of Ru(II) Polypyridyl Complexes, C. V. Kumar, J. K. Barton, N. J. Turro and I. R. Gould, Inorg. Chem., 27, 648-51 (1987). 7

36. On the Factors Influencing the Excited State Behavior of Ruthenium Complexes Adsorbed on Aqueous Laponite, N. J. Turro, Z. Grauer and C. V. Kumar, Langmuir, 3, 1056-59 (1987).

35. Time-Resolved Excited State Raman Spectra of Ru(II) Complexes, C. V. Kumar, N. J. Turro and J. K. Barton, Inorg. Chem., 26, 1455-1457 (1987).

34. DNA Mediated Photoelectron Transfer Reactions, J. K. Barton, C. V. Kumar and N. J. Turro, J. Am. Chem. Soc., 108, 6391-93 (1986).

33. Probing Nucleic Acid Structure with Metallointercalators, C. V. Kumar, A. L. Raphael and J. K. Barton, J. Biomol. Struct. Dyn., 3, 85-101 (1986).

32. Photoinduced Ring Enlargement Reactions of 2H-1,2,4-Benzothiadiazine 1,1-Dioxides. Steady-State and Laser Flash Photolysis Studies, C. V. Kumar, K. R. Gopidas, K. Bhattacharyya, P. K. Das and M. V. George J. Org. Chem., 51, 1967-72 (1986).

31. Binding Modes and Base Specificity of tris(phenanthroline)Ru(II) Enantiomers with Nucleic Acids: Tuning the Stereoselectivity, J. K. Barton, J. M. Goldberg, C. V. Kumar and N. J. Turro, J. Amer. Chem. Soc., 108, 2081-88 (1986).

30. Photophysical Properties of Ruthenium Complexes Bound to Double Helical DNA, C. V. Kumar, J. K. Barton and N. J. Turro, J. Amer. Chem. Soc., 107, 5518-24 (1985).

29. Inverse Temperature Dependence of Dipolarophile Reactivity of Carbonyl Ylide, Photogenerated from trans-Stilbene Oxide, S. K. Chattopadhyay, C. V. Kumar and P. K. Das, J. Photochem., 34, 35-42 (1986).

28. Photoinduced Electron Transfer Reactions of 2(3H)-Furanones and bis (benzofuranones). Spectral and Kinetic Behavior of Radicals and Radical Cations, H. F. Davis, B. B. Lohray, K. R. Gopidas, C. V. Kumar, P. K. Das and M. V. George, J. Org. Chem., 50, 3685-92 (1985).

27. Anamolous Temperature Dependence of Cycloaddition Reactions of Crbonyl Ylides Towards Some Dipolarophiles, C. V. Kumar, S. K. Chattopadhyay and P. K. Das, J. Phys. Chem., (1985).

26. Photochemistry of a- Epoxy Ketones. Substituent Effects on Oxirane Ring Opening and Related Behavior, C. V. Kumar, D. Ramaiah, P. K. Das and M. V. George, J. Org. Chem., 50, 2818-24 (1985).

25. A Laser Flash Photolysis Study of Aliphatic Thioketone Triplets. Self Quenching and Singlet Oxygen Sensitization, K. Bhattacharyya, C. V. Kumar, P. K. Das, B. Jayasree and V. Ramamurthy, Faraday Trans., II 81, 1383-93 (1985).

24. Photoprocesses in Diphenyl Polyenes. 3. Efficiency of Singlet Oxygen Generation from Oxygen Quenching of Polyene Singlets and Triplets, S. K. Chattopadhyay, C. V. Kumar and P. K. Das, J. Phys. Chem., 89, 670-73 (1985).

23. Substituent Effects in the Quenching of Acetophenone and Benzophenone Triplets by Oxygen and Di-t-butylnitroxy Radical and Inefficiency of Singlet Oxygen Photogeneration, S. K.Chattopadhyay, C. V. Kumar and P. K. Das, J. Phys. Chem., 30, 81-91 (1985).

22. Triplet Excitation Transfer Involving b-Ionone. A Kinetic Study by Laser Flash Photolysis, S. K. Chattopadhyay, C. V. Kumar and P. K. Das, Photochem. Photobiol., 42, 17-24 (1985).

21. Steady State and Laser Flash Photolysis Investigations of 1-Aziridyl-1,2-dibenzoyl-alkenes, R. Barikh, C. V. Kumar, P. K. Das and M. V. George, J. Org. Chem., 50, 4309-17 (1985).

20. Carbonyl Ylides Photogenerated from Isomeric Stilbene Oxides. Temperature Dependence of Decay Kinetics, C. V. Kumar, S. K. Chattopadhyay and P. K. Das, J. Phys. Chem., 88, 5639-43 (1984).

19. Steady-state and Laser Flash Photolysis of Bridge-head Substituted Dibenzobarrelenes, B. A. R. C. Murty, S. Pratapan, C. V. Kumar, P. K Das and M. V. George, J. Org. Chem., 50, 2533-38 (1984).

18. Photophysical Behaviours of N-Methylthioacridone Triplet and Efficiency of Singlet Oxygen Generation from its Quenching by Oxygen, C. V. Kumar, F. H. Davis and P. K. Das, Chem. Phys. Lett., 109, 184-89 (1984).

17. Phototransformations of 11,12-Dibenzoyl-9,10-dihydro-9,10-ethenoanthracenes, C. V. Kumar, B. A. R. C. Murty, S. Lahiri, E. Chakachery J. C. Scaiano and M. V. George, J. Org. Chem., 49, 4923-29 (1984).

16. Geminate Reverse Electron Transfer in Photogenerated Ion Pair. Mechanism of 1,4-Dicyanonaphthalene Sensitized Ylide Formation from Stilbene Oxides, C. V. Kumar, S. K. Chattopadhyay and P. K. Das, Chem. Comm., 1107-09 (1984).

15. Photochemical Transformations and Laser Flash Photolysis Studies of 1,4- and 1,2-Epoxy Compounds Containing 1,2-Dibenzoylalkene Moieties, B. A. R. C. Murty, C. V. Kumar, V. Dabral, P. K. Das and M. V. George, J. Org. Chem., 49, 4165-71 (1984).

14. Photochemical Transformations of 1-Pyrazolyl-cis-1,2-dibenzoylalkenes. A Laser Flash Photolysis Investigation, B. B. Lohray, C. V. Kumar, P. K. Das and M. V. George, J. Org. Chem., 49, 4647-56 (1984). 8

13. Photochemical and Thermal Transformations of Some 2(3H)Furanones and Bisbenzofuranones, B. B. Lohray, C.V. Kumar, P.K. Das and M.V. George, J. Am. Chem. Soc., 106, 7352-59 (1984).

12. Short-lived Olefin Triplets and Energy Transfer from them to b-carotene, C. V. Kumar, S. K. Chattopadhyay and P. K. Das, Chem. Phys. Lett., 106, 431-36 (1984).

11. A Laser Flash Photolysis Study of Aromatic Keto-epoxides. Characterization of Ylides and Their Precursors, C. V. Kumar, P. K. Das, W. I. O'Sullivan, S. N. Ege, G. W. Griffin, J.C. S. Perkin Trans., II, 1745-50 (1984).

10. Aromatic Thioketone Triplets and their Quenching Behavior Towards Oxygen and Di-tert-butylnitroxy Radical. A Laser Flash Photolysis Study, C. V. Kumar, L. Qin, P. K. Das, J. C. S. Faraday Trans. II, 80, 783-93 (1984).

9. Triplet State Photophysics of Retinal Analogues. Interaction of Polyene Triplets with Di-t-butyl nitroxy Radical, S. K.Chattopadhyay, C. V. Kumar and P. K. Das, J. Chem. Soc. Fraday Trans., I, 80,1151-61 (1984).

8. Laser Flash Photolytic Determination of Triplet Yields via Singlet Oxygen, S. K. Chattopadhyay, C. V. Kumar and P. K. Das, J. Photochem., 24, 1-9 (1984).

7. Role of Geometric Distortion in the Quenching Behaviors of All trans-1,4-Diphenyl-1,3-butadiene Triplet, S. K. Chattopadhyay, C. V. Kumar and P. K.Das, J. Photochem., 26, 39-47 (1984).

6. A Laser Flash Photolysis Study of Pyrene-1-aldehyde. Intersystem Crossing Efficiency, Photoreactivity and Triplet State Properties in Various Solvents, Ch. V. Kumar, S. K. Chattopadhyay and P. K. Das, Photochem. Photobiol., 38, 141-52 (1983).

5. Triplet Excitation Transfer to Carotenoids from Biradical Intermediates in Norrish Type II Photoreactions of o-Alkyl Substituted Carbonyl Compounds, C. V. Kumar, S. K. Chattopadhyay and P. K. Das, J. Amer. Chem. Soc., 105, 5143-44 (1983).

4. Triplet Related Photophysics of 9,10-Diphenylanthracene. A Kinetic Study of Reversible Energy Transfer from Anthracene Triplet by Nanosecond Flash Photolysis, S. K. Chattopadhyay, Ch. V. Kumar and P. K. Das, Chem. Phys. Lett., 98, 250-54 (1983).

3. Photochemical Transformations of cis-1,2-Dibenzoylalkenes, S. Lahiri, V. Dabral, S. M. S. Chauhan, E. A. Chakachery, Ch. Vijaya Kumar, J. C. Scaiano and M. V. George, J. Org. Chem., 45, 3782 (1982).

2. Photochemistry and Photooxidation of Tetraphenyl-p-dioxin, M. V. George, Ch. Vijaya Kumar and J. C. Scaiano, J. Phys. Chem., 83, 2452 (1979).

1. Synthesis of (E,E)-1,4-Diaryl-1,3-butadienes, V. V. Ramana Rao, Ch. Vijaya Kumar and D. Devaprabhakara, J. Organometal. Chem., 179, c7-c9 (1979).

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Challa V. Kumar, PhD, Professor of Biological and Physical Chemistry

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Professor Challa Vijaya Kumar Receives Faculty Excellence Award:           Click here to view the Video